Admission arterial oxygen saturation was significantly lower in composite versus control group (93.4% vs 97.1% p = 0.005). Alveolar dead-space fraction greater than or equal to 0.29 indicated a 37% increase in risk to meet composite criteria. ![]() Alveolar dead-space fraction was significantly higher in the composite (0.33 ± 0.14) versus control (0.25 ± 0.26 p = 0.016) group. Of 128 patients undergoing Fontan operation, 34 met criteria for composite outcome. Secondary endpoints were parameters of severity of illness, chest drainage duration, and length of stay. Associations between alveolar dead-space fraction and arterial oxyhemoglobin saturation to a composite outcome (surgical or catheter-based intervention, extracorporeal membrane oxygenation use, prolonged ventilation, prolonged hospital length of stay, or death) were explored. The association of alveolar dead-space fraction with clinical outcomes in patients undergoing Fontan operation has not been reported.Ī retrospective charts review of all pediatric patients who underwent Fontan surgery during June 2010-November 2018 in a tertiary-care pediatric hospital. Increased alveolar dead-space fraction has been associated with prolonged mechanical ventilation and worse outcome after congenital heart surgery. Alveolar dead-space fraction represents the portion of inhaled air that does not participate in gas exchange and hence quantifies ventilation-perfusion abnormalities in the lung. A decrease in pulmonary blood flow can lead to major complications and grave outcomes. ![]() Fontan surgery, the final surgical stage in single ventricle palliation, redirects systemic venous blood into the pulmonary circulation for gas exchange.
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